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  4. Mouse Macrophage Inflammatory Protein 1β,MIP-1β ELISA kit

Mouse Macrophage Inflammatory Protein 1β,MIP-1β ELISA kit

  • 中文名称：
    小鼠巨噬细胞炎性蛋白1β(MIP-1β/CCL4)酶联免疫试剂盒
  • 货号：
    CSB-E04665m
  • 规格：
    96T/48T
  • 价格：
    ￥3200/￥2500
  • 其他：

产品详情

  • 产品描述：
    小鼠巨噬细胞炎性蛋白1β(MIP-1β/CCL4)酶联免疫试剂盒（CSB-E04665m）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织匀浆样本中的CCL4含量。CCL4，即C-C趋化因子配体4，是一种由免疫细胞和肿瘤细胞分泌的细胞因子，主要在正常组织中不表达或弱表达，但在多种恶性肿瘤组织中异常高表达。CCL4与CCR5受体结合后，可招募免疫细胞，破坏肿瘤微环境稳定性，参与致癌并促进肿瘤发展。其研究机制涉及调节肿瘤微环境中的免疫细胞组成和功能，对肿瘤的发生发展及免疫逃逸有重要影响。试剂盒检测范围为12.5 pg/mL-800 pg/mL，本试剂盒采用特异性抗体对目标蛋白进行捕获与检测，操作流程标准化，适用于科研领域中对小鼠模型炎症相关机制的研究，例如在感染性疾病模型、自身免疫疾病模型或免疫调节实验中定量分析MIP - 1β/CCL4的表达动态，亦可应用于药物开发或免疫干预研究中评估该趋化因子的水平变化。实验支持多种生物样本类型检测，为探索炎症微环境及免疫调控网络提供可靠工具。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
  • 别名：
    Ccl4 ELISA Kit; Mip1b ELISA Kit; Scya4 ELISA Kit; C-C motif chemokine 4 ELISA Kit; Immune activation protein 2 ELISA Kit; ACT-2 ELISA Kit; ACT2 ELISA Kit; Macrophage inflammatory protein 1-beta ELISA Kit; MIP-1-beta ELISA Kit; Protein H400 ELISA Kit; SIS-gamma ELISA Kit; Small-inducible cytokine A4 ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    12.5 pg/mL-800 pg/mL
  • 灵敏度：
    3.12 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：

  • 线性度：

  • 回收率：

  • 标准曲线：

  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Monokine with inflammatory and chemokinetic properties.
  • 基因功能参考文献：
    1. CCL4-CCR5 axis can contribute to breast cancer metastasis to bone by mediating the interaction between cancer cells and fibroblasts in bone cavity. PMID: 27177471
    2. YY1 regulates lung CCL4 transcription in pulmonary tuberculosis. PMID: 26786659
    3. Ccl4 mRNAs increased within 5 h after injury in mouse cortical slices. PMID: 25895671
    4. CCL4 and CCL5 expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4 T cells from WSX-1(-/-) mice expressed higher levels of CCR5 than cells from WT mice PMID: 24244314
    5. CCL4 upregulation was associated with increased Snail expression and downregulation of p53/PTEN in high-grade PIN and prostate cancer PMID: 23878190
    6. These results suggest that MIP-1beta is a novel key mediator, and the peripheral MIP-1beta-CCR5 axis contributes to neuropathic pain. PMID: 22528550
    7. results indicate that MIP-1beta is involved in the recruitment of bone marrow-derived monocyte lineage cells PMID: 21912378
    8. increased responsiveness of murine eosinophils to MIP-1beta is mediated by CCR5 receptor in mice PMID: 12050188
    9. macrophage inflammatory protein-1beta is a hypoxia-induced neutrophil survival factor. PMID: 15630139
    10. MIP-1beta is overexpressed, and VE-cadherin is underexpressed in heart transplant allografts compared with isografts PMID: 15897346
    11. Overproduction of MIP-1beta in chemokine (C-C motif) receptor 5-deficient mice after collagen II-immunization may contribute partially to the occurrence of arthritis PMID: 15967376
    12. The expression and role CXCL12 and CCL4 and their receptors (CXCR4 and CCR5) in regulating thymocyte migration in conjunction with extracellular matrix during acute T. cruzi infection are investigated. PMID: 16637021
    13. ATF3 appears to be part of a control mechanism that limits the amount of CCL4 released by macrophages, preventing excessive inflammation. PMID: 16982098
    14. Antibody neutralization of CCL4 abrogates the ability of T-cells from IL-4-treated NOD mice to transfer protection against type 1 diabetes. PMID: 17327452

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 数据库链接：


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