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ADAM19 Antibody

  • 中文名称：
    ADAM19兔多克隆抗体
  • 货号：
    CSB-PA880929ESR1HU
  • 规格：
    ￥440
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA880929ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA880929ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ADAM19 Polyclonal antibody
  • Uniprot No.：
    Q9H013
  • 基因名：
    ADAM19
  • 别名：
    ADAM19 antibody; MLTNB antibody; FKSG34Disintegrin and metalloproteinase domain-containing protein 19 antibody; ADAM 19 antibody; EC 3.4.24.- antibody; Meltrin-beta antibody; Metalloprotease and disintegrin dendritic antigen marker antibody; MADDAM antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 19 protein (203-460AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

靶点详情

  • 功能：
    Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone.
  • 基因功能参考文献：
    1. 3 SNPs (rs4329505 and rs4845626 in interleukin 6 receptor [IL6R] and rs1422794 in a disintegrin and metalloproteinase domain 19 [ADAM19]) were associated with a lower risk of suffering the most severe stages of the disease. PMID: 27078193
    2. ADAM19 is a protective factor for human prostate cancer. Further, this study suggests that upregulation of ADAM19 expression could be of therapeutic potential in human prostate cancer. PMID: 26912236
    3. these findings suggested that miR-145 functions as a tumor suppressor in RB by directly targeting ADAM19 in retinoblastoma cells PMID: 26823772
    4. miR-30c inhibited colon cancer cells via targeting ADAM19. PMID: 25799050
    5. four suggestive loci (PAX3, CCRN4L, PIGQ, and ADAM19)determinants of disease progression in Alzheimer's disease. PMID: 25114068
    6. ADAM19 rs1422795 and HTR4 rs11168048 are associated with pulmonary function. PMID: 24951661
    7. MiR-153 has a role in inhibiting migration and invasion of human non-small-cell lung cancer by targeting ADAM19 PMID: 25475731
    8. ADAM19 was upregulated in patients with ulcerative colitis and, to a lesser extent, in patients with Crohn's disease compared with normal controls. In contrast, ADAM9 and ADAM10 expression did not differ between patients with IBD and controls. PMID: 23429442
    9. Prorenin receptor is mainly localized in the subcellular organelles, such as the endoplasmic reticulum and Golgi apparatus, and the prorenin receptor is cleaved by ADAM19 in the Golgi, resulting in two fragments. PMID: 21270819
    10. Single nucleotide polymorphisms in ADAM19 gene is associated with lymphoma. PMID: 21239057
    11. These findings suggest that ADAM19 autolysis is activated by lipopolysaccharide and that ADAM19 promotes the secretion of CRIP2. PMID: 20460109
    12. ADAM19 correlates with the progress and prognosis of endometrial carcinoma. PMID: 18458692
    13. ADAM19 may participate in the coordinated regulation of human trophoblast cell behaviors during the process of placentation. PMID: 19727588
    14. activation by furin via one of two consecutive recognition sites PMID: 12006600
    15. investigation of proteolytic activity PMID: 12393862
    16. yeast two-hybrid screen performed in fetal brain cDNA library isolated four proteins that interact with the cytoplasmic tail of ADAM19 PMID: 12463424
    17. A new autolytic processing site at Lys543-Val544 was identified in soluble mutants of ADAM19 when these cysteine residues were individually mutated to serine residues. PMID: 15242783
    18. ChIP assays demonstrated high levels of acetylated histone H3 in the promoter region of the MADDAM gene in TSA-treated THP-1 cells/dendritic cells compared to macrophages, indicating an important role of histone acetylation in regulating the MADDAM gene. PMID: 15896713
    19. ADAM19 may have a modulatory role in the dysfunctional renal allograft state PMID: 16827870
    20. results suggest that ADAM19 has a constitutive alpha-secretase activity for amyloid precursor protein PMID: 17112471
    21. we suggest that epigenetic dysregulation of ADAM19 may contribute to the neoplastic process in ovarian cancer. PMID: 18714391

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in many normal organ tissues and several cancer cell lines.
  • 数据库链接：

    HGNC: 197

    OMIM: 603640

    KEGG: hsa:8728

    STRING: 9606.ENSP00000257527

    UniGene: Hs.483944