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DOCK6 Antibody

  • 中文名称：
    DOCK6兔多克隆抗体
  • 货号：
    CSB-PA846633LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA846633LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DOCK6 Polyclonal antibody
  • Uniprot No.：
    Q96HP0
  • 基因名：
    DOCK6
  • 别名：
    Dedicator of cytokinesis protein 6 antibody; Dock6 antibody; DOCK6_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dedicator of cytokinesis protein 6 protein (499-616AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DOCK6 Antibody (CSB-PA846633LA01HU)，的标记方式是Non-conjugated。对于DOCK6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA846633LB01HU DOCK6 Antibody, HRP conjugated ELISA
    FITC CSB-PA846633LC01HU DOCK6 Antibody, FITC conjugated
    Biotin CSB-PA846633LD01HU DOCK6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth.
  • 基因功能参考文献：
    1. acute knockdown of the Adams-Oliver syndrome (AOS) gene DOCK6, coding for a RAC1/CDC42 guanine nucleotide exchange factor, results in strikingly different phenotypes to those generated by genomic DOCK6 disruption. PMID: 27693507
    2. this study demonstrates that miR-142-3p is a key regulator of the TGFbeta-mediated contractile phenotype of VSMCs that acts through inhibiting cell migration through targeting DOCK6. PMID: 25832008
    3. DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomalies PMID: 25824905
    4. A homozygous truncating mutation in dedicator of cytokinesis 6 gene (DOCK6) which encodes an atypical guanidine exchange factor (GEF) known to activate two members of the Rho GTPase family: Cdc42 and Rac1, was identified. PMID: 21820096
  • 相关疾病：
    Adams-Oliver syndrome 2 (AOS2)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly located near the cell surface.
  • 蛋白家族：
    DOCK family
  • 组织特异性：
    Widely expressed. Expressed at low level in spleen, cerebellum, hippocampus and in substantia nigra.
  • 数据库链接：

    HGNC: 19189

    OMIM: 614194

    KEGG: hsa:57572

    STRING: 9606.ENSP00000294618

    UniGene: Hs.591002