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EEF1E1 Antibody

  • 中文名称：
    EEF1E1兔多克隆抗体
  • 货号：
    CSB-PA007432GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O43324
  • 基因名：
    EEF1E1
  • 别名：
    AIMP 3 antibody; AIMP3 antibody; Aminoacyl tRNA synthetase complex interacting multifunctional protein 3 antibody; Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3 antibody; ARS interacting multifunctional protein 3 antibody; EEF1E1 antibody; Elongation factor p18 antibody; Eukaryotic translation elongation factor 1 epsilon 1 antibody; Eukaryotic translation elongation factor 1 epsilon-1 antibody; Homolog of rat elongation factor p18 antibody; MCA3_HUMAN antibody; Multisynthase complex auxiliary component p18 antibody; Multisynthetase complex auxiliary component p18 antibody; p18 antibody; p18 component of aminoacyl tRNA synthetase complex antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human EEF1E1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Positive modulator of ATM response to DNA damage.
  • 基因功能参考文献：
    1. LmnA binds AIMP3 via its extreme C-terminus. Together these findings provide a structural insight for understanding the interaction between AIMP3 and LmnA in AIMP3 degradation. PMID: 28797100
    2. AIMP3 was shown to be involved in the cellular aging of human mesenchymal stem cells. PMID: 25465621
    3. Identification of EEf1E1 and OBFC2B as novel BRCA1-partner genes in the DNA double-strand break repair pathway. PMID: 24104880
    4. AIMP3 stabilizes and protects methionyl-tRNA synthetase and eIF2gamma through the binding interactions. PMID: 23306449
    5. AIMP3 is a critical mediator of Met-tRNA(i)(Met) transfer from methionyl-tRNA synthetase to eIF2 complex for the accurate and efficient translation initiation PMID: 22867704
    6. Data show that aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3)/p18 is released from aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3) by UV irradiation-induced stress. PMID: 22106287
    7. Decreased expression of AIMP3 in gastric and colorectal cancer tissues suggests that down-regulation of this protein may be related to inactivation of the tumor suppressor functions of AIMP proteins and might play a role in the development of GC and CRC. PMID: 21789020
    8. p18 is a haploinsufficient tumor suppressor and a key factor for ATM/ATR-mediated p53 activation. PMID: 15680327
    9. analysis of the three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with PMID: 18343821
    10. No EEF1E1 mutations were detected in human cancer specimens. PMID: 19024604

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytosol. Nucleus. Note=Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage.
  • 组织特异性：
    Down-regulated in various cancer tissues.
  • 数据库链接：

    HGNC: 3212

    OMIM: 609206

    KEGG: hsa:9521

    STRING: 9606.ENSP00000369038

    UniGene: Hs.602353