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  4. TRPC7 Antibody

TRPC7 Antibody

  • 中文名称：
    TRPC7兔多克隆抗体
  • 货号：
    CSB-PA954426
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA954426(TRPC7 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA954426(TRPC7 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9HCX4
  • 基因名：
    TRPC7
  • 别名：
    Capacitative calcium channel TRPC7 antibody; cation channel; subfamily C; member 7 antibody; hTRP7 antibody; KNP3 antibody; Likley ortholog of mouse transient receptor potential cation channel subfamily C member 7 antibody; mTRP7 antibody; Putative capacitative calcium channel antibody; Short transient receptor potential channel 7 antibody; Transient receptor potential cation channel subfamily C member 7 antibody; transient receptor potential-related channel 7; a novel putative Ca2+ channel protein antibody; Transient receptor protein 7 antibody; TRP 7 antibody; TRP-7 antibody; TRP7 protein antibody; TRPC 7 antibody; TrpC7 antibody; Trpc7 transient receptor potential cation channel; subfamily C; member 7 antibody; TRPC7_HUMAN antibody; TRPM2 antibody; Trrp8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human TRPC7
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion.
  • 基因功能参考文献：
    1. A fundamental role for PI(4,5)P2 was identified in the regulation of TRPC7 and TRPC6. PMID: 24470487
    2. Phosphorylation of transient receptor potential cation channel subfamily C member 7 significantly suppressed carbachol-induced calcium influx and CREB phosphorylation. PMID: 21402151
    3. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx PMID: 11805119
    4. can be activated by both receptor- and store-operated modes in the same cell. PMID: 15342342
    5. endogenous TRPC1, TRPC3, and TRPC7 participate in forming heteromeric store-operated channels, whereas TRPC3 and TRPC7 can also participate in forming heteromeric receptor-operated channels. PMID: 15972814
    6. in B-lymphocytes, TRPC7 appears to participate in the formation of ion channels that could be activated by phospholipase C-linked receptors PMID: 16123040
    7. activation of both muscarinic and purinergic receptors via a common DAG-dependent link opens Ca(2+)-permeable TRPC7 channels PMID: 16741513
    8. the physiological importance of TRPC7 in the native environment remains elusive, TRPC7 would play important roles in Ca2+ signaling pathway--{REVIEW} PMID: 17217055
    9. Expression and activity of TRPM7 is modulated by extracellular Mg2+ and Ca2+ availability, indicating that TRPM7 channels are involved in intracellular ion homeostasis and proliferation of osteoblasts. PMID: 18021175
    10. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 or TRPC7 protein induce enhanced receptor-activated Ca(2+) influx that may lead to dysregulated cell growth in ADPKD PMID: 19812035

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Nucleus envelope.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC7 sub-subfamily
  • 数据库链接：

    HGNC: 20754

    KEGG: hsa:57113

    STRING: 9606.ENSP00000426070

    UniGene: Hs.591263