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  4. Recombinant Human Neuropeptide S (NPS)

Recombinant Human Neuropeptide S (NPS)

  • 中文名称：
    人NPS重组蛋白
  • 货号：
    CSB-YP016026HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NPS重组蛋白
  • 货号：
    CSB-EP016026HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NPS重组蛋白
  • 货号：
    CSB-EP016026HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NPS重组蛋白
  • 货号：
    CSB-BP016026HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NPS重组蛋白
  • 货号：
    CSB-MP016026HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NPS
  • Uniprot No.：
  • 别名：
    Neuropeptide S; Nps; NPS_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    70-89
  • 氨基酸序列
    S FRNGVGTGMK KTSFQRAKS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations.
  • 基因功能参考文献：
    1. SNPs modify asthma risk PMID: 28463995
    2. A SNP within the neuropeptide s gene is associated with decreased bioactivity. PMID: 24386135
    3. NPS is able to stimulate human monocyte chemotaxis and that this effect is entirely due to selective NPSR activation. PMID: 23142110
    4. The available information regarding NPS and its receptor and the biological actions modulated by the NPS-NPSR system, is summarized. PMID: 19824051
    5. NPS-NPSR1 signaling is likely involved in anxiety PMID: 20705147
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 20705147
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20405330
    8. NPS has a novel role in the stimulation of the hypothalamo-pituitary-adrenal axis PMID: 16574794
    9. the C-terminal region of neuropeptide S maintains importance for in vivo activity PMID: 16720571
    10. the key residues of NPS involved in NPSR activation and suggest a molecular basis for the functional effects of the N107I mutation and for its putative pathophysiological link with asthma PMID: 16790440
    11. Because remodeling of airway epithelium is a feature of chronic asthma, the up-regulation of MMP10 and TIMP3 by NPS-NPSR1 signaling may be of relevance in the pathogenesis of asthma. PMID: 16926187
    12. NPS acts as a novel modulator of arousal and anxiety-related behaviours by promoting a unique pattern of effects: stimulation associated with anxiolysis. PMID: 18376418
    13. Observational study of gene-disease association. (HuGE Navigator) PMID: 19240061

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    HGNC: 33940

    OMIM: 609513

    KEGG: hsa:594857

    STRING: 9606.ENSP00000381105

    UniGene: Hs.643423