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  4. Recombinant Mouse Amino-terminal enhancer of split (Aes)

Recombinant Mouse Amino-terminal enhancer of split (Aes)

  • 中文名称：
    Recombinant Mouse Amino-terminal enhancer of split(Aes),Yeast
  • 货号：
    CSB-YP001405MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Amino-terminal enhancer of split(Aes),Yeast
  • 货号：
    CSB-EP001405MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Amino-terminal enhancer of split(Aes),Yeast
  • 货号：
    CSB-EP001405MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Amino-terminal enhancer of split(Aes),Yeast
  • 货号：
    CSB-BP001405MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Amino-terminal enhancer of split(Aes),Yeast
  • 货号：
    CSB-MP001405MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Aes
  • Uniprot No.：
  • 别名：
    Tle5; Aes; Esp1; Grg; Grg5; TLE family member 5; Amino-terminal enhancer of split; Amino enhancer of split; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-197
  • 氨基酸序列
    MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL ASEKSEMQRH YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTAPELN SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQTHLSKEDK NGHDGDTHQE DDGEKSD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
  • 基因功能参考文献：
    1. in a transplantation mouse model of liver metastases, expression of Yy2 (and therefore of Aes) is downregulated PMID: 27561171
    2. The Aes gene functions as an endogenous metastasis suppressor. Aes inhibits Notch signaling by converting active Rbpj transcription complexes into repression complexes on insoluble nuclear matrix. PMID: 21251616
    3. Data suggest that Grg5 modulates the activities of transcription factors in vivo to affect Ihh expression and the function of long bone growth plates. PMID: 11984876
    4. Tcf4 and Aes influence pituitary growth and development, and place Tcf4 and Tle3 in the genetic hierarchy with Prop1 PMID: 12907761
    5. Grg5 acts as a positive regulator of Runx2 activity and is necessary for full expression and signalling of Indian hedgehog (Ihh). PMID: 15183720
    6. Data show that GRG proteins, including GRG5, interact with two regulators of GnRH transcription, the homeodomain proteins MSX1 and OCT1, and regulate GnRH promoter activity. PMID: 16002402

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat Groucho/TLE family
  • 组织特异性：
    Ubiquitously expressed in developing embryos by midgestation, a wide expression is conserved in adult. In mouse, abundantly expressed in muscle, heart and brain.
  • 数据库链接：

    KEGG: mmu:14797

    STRING: 10090.ENSMUSP00000002518

    UniGene: Mm.180013