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  4. Recombinant Mouse Killer cell lectin-like receptor 3 (Klra3), partial

Recombinant Mouse Killer cell lectin-like receptor 3 (Klra3), partial

  • 中文名称：
    小鼠Klra3重组蛋白
  • 货号：
    CSB-YP720664MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Klra3重组蛋白
  • 货号：
    CSB-EP720664MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Klra3重组蛋白
  • 货号：
    CSB-BP720664MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Klra3重组蛋白
  • 货号：
    CSB-MP720664MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Klra3
  • Uniprot No.：
  • 别名：
    Klra3; Ly-49c; Ly49C; Killer cell lectin-like receptor 3; 5E6; Lymphocyte antigen 49c; Ly-49c; Nk2.1; T-cell surface glycoprotein Ly-49C
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor on natural killer (NK) cells for class I MHC.
  • 基因功能参考文献：
    1. This docking mode was conserved with that previously observed for Ly49C.H-2K(b) Indeed, structure-guided mutation of Ly49C indicated that Ly49C.H2-Q10 and Ly49C.H-2K(b) possess similar energetic footprints focused around residues located within the Ly49C beta4-stand and L5 loop, which contact the underside of the peptide-binding platform floor. PMID: 27385590
    2. murine cytomegalovirus infection results in altered NK cell activation PMID: 24873973
    3. we have shown for the first time how the differential expression of the Ly49 inhibitory receptors during ontogeny can affect NK cell function PMID: 23960238
    4. This study showed that mPer2 is a critical clock component in modulating circadian rhythms in bone marrow, and it implies that Ly49C and Nkg2d may play an important role in mediating mPer2-controlled cytotoxic response. PMID: 20030538
    5. Three mutations have been introduced in Ly49C that correspond to Ly49A residues close to H-2Dd in the co-crystal, demonstrating that MHC class I binding by Ly49C is dependent on residues in the same area as that used by Ly49A for ligand contacts. PMID: 11777974
    6. signaling through the mouse NK inhibitory receptor Ly49C requires the presence of H-2Kb and this signaling is prevented when H-2Kb is ablated by pulsing with a peptide that can bind to it with high affinity PMID: 16148097
    7. adoptive infusion of alloreactive NK cells with silenced Ly49C gene results in suppression of graft-versus-host disease PMID: 19010415

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 数据库链接：

    KEGG: mmu:16634

    STRING: 10090.ENSMUSP00000085333

    UniGene: Mm.425338