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  4. Recombinant Rat Inhibin alpha chain (Inha)

Recombinant Rat Inhibin alpha chain (Inha)

  • 中文名称：
    大鼠Inha重组蛋白
  • 货号：
    CSB-YP011718RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Inha重组蛋白
  • 货号：
    CSB-EP011718RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Inha重组蛋白
  • 货号：
    CSB-EP011718RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Inha重组蛋白
  • 货号：
    CSB-BP011718RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Inha重组蛋白
  • 货号：
    CSB-MP011718RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Inha
  • Uniprot No.：
  • 别名：
    Inha; Inhibin alpha chain
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    234-366
  • 氨基酸序列
    SAPSMPW PWSPAALRLL QRPPEEPSAH AFCHRAALNI SFQELGWDRW IVHPPSFIFH YCHGSCGMPT SDLPLPVPGA PPTPAQPLFL VPGAKPCCAA LPGSMRSLRV RTTSDGGYSF KYEMVPNLIT QHCACI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
  • 基因功能参考文献：
    1. Inhba overexpression in rat ovary in vivo may change reproductive endocrine function. PMID: 23767829
    2. Both the hormonal milieu of perimenopause and the association of dynamic perimenopausal changes in FSH and inhibin A with decreased bone mineral density have been reproduced in an animal model. PMID: 22249524
    3. beta-catenin synergizes with steroidogenic factor-1 to activate the alpha-inhibin promoter through formation of a transcriptional complex PMID: 12732619
    4. Within the testis, inhibin A levels fall from 0.330 +/- 0.108 ng/g at d 15 to less than 0.004 ng/g at maturity. PMID: 15070852
    5. Data indicate that the inhibin alpha subunit influences a number of the reproductive functions of female mice. PMID: 15359127
    6. there are two distinct mechanisms by which C/EBPbeta represses inhibin alpha-subunit gene expression in ovarian granulosa cells. PMID: 15650079
    7. the mechanisms of Inhibin-alpha repression by ICER PMID: 16269517
    8. findings revealed that each granulosa cell expresses a stable amount of inhibin-alpha subunit mRNA independently of antral formation in immature rat ovaries PMID: 16770574
    9. Betaglycan is an endogenous inhibin coreceptor required for high-sensitivity inhibin antagonism of activin signaling in rat anterior pituitary gonadotropes. PMID: 19372236
    10. The effect of steroidogenic substrates and follicle stimulating hormone on steroid, inhibin A and B, Pro-alphaC and activin A production was evaluated. PMID: 19464342

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 组织特异性：
    Mainly expressed in ovary and testis. Alpha- and beta-B-subunits are the predominant forms found in testis. Also found in placenta, pituitary, adrenal gland, bone marrow, kidney, spinal chord and brain.
  • 数据库链接：

    KEGG: rno:24504

    STRING: 10116.ENSRNOP00000027227

    UniGene: Rn.8831