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  4. Recombinant Arabidopsis thaliana Putative cyclic nucleotide-gated ion channel 18 (CNGC18)

Recombinant Arabidopsis thaliana Putative cyclic nucleotide-gated ion channel 18 (CNGC18)

  • 中文名称：
    Recombinant Arabidopsis thaliana Putative cyclic nucleotide-gated ion channel 18(CNGC18)
  • 货号：
    CSB-CF878476DOA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    CNGC18
  • Uniprot No.：
  • 别名：
    CNGC18; At5g14870; T9L3_170; Cyclic nucleotide-gated ion channel 18; Cyclic nucleotide- and calmodulin-regulated ion channel 18
  • 种属：
    Arabidopsis thaliana (Mouse-ear cress)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-706
  • 氨基酸序列
    MNKIRSLRCLLPETITSASTAASNRGSDGSQFSVLWRHQILDPDSNIVTYWNHVFLITSI LALFLDPFYFYVPYVGGPACLSIDISLAATVTFFRTVADIFHLLHIFMKFRTAFVARSSR VFGRGELVMDSREIAMRYLKTDFLIDVAAMLPLPQLVIWLVIPAATNGTANHANSTLALI VLVQYIPRSFIIFPLNQRIIKTTGFIAKTAWAGAAYNLLLYILASHVLGAMWYLSSIGRQ FSCWSNVCKKDNALRVLDCLPSFLDCKSLEQPERQYWQNVTQVLSHCDATSSTTNFKFGM FAEAFTTQVATTDFVSKYLYCLWWGLRNLSSYGQNITTSVYLGETLFCITICIFGLILFT LLIGNMQSSLQSMSVRVEEWRVKRRDTEEWMRHRQLPPELQERVRRFVQYKWLATRGVDE ESILHSLPTDLRREIQRHLCLSLVRRVPFFSQMDDQLLDAICGCLVSSLSTAGTYIFREG DPVNEMLFVIRGQIESSTTNGGRSGFFNSTTLRPGDFCGEELLTWALMPNSTLNLPSSTR SVRALSEVEAFALSAEDLKFVAHQFKRLQSKKLQHAFRYYSHQWRAWGACFVQSAWRRYK RRKLAKELSLHESSGYYYPDETGYNEEDEETREYYYGSDEEGGSMDNTNLGATILASKFA ANTRRGTNQKASSSSTGKKDGSSTSLKMPQLFKPDEPDFSIDKEDV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cyclic nucleotide-gated ion channel required for directional pollen tube growth into the transmitting tract. Acts as a Ca(2+)-permeable divalent cation-selective channel inhibited by either lanthanum or gadolinium. Regulated by CPK32 to mediate Ca(2+) transport across the plasma membrane in response to Ca(2+) oscillation.
  • 基因功能参考文献：
    1. Data demonstrate that CNGC18 plays essential roles in pollen germination and tube growth as a Ca(2+) channel in Arabidopsis. PMID: 27322818
    2. Among 8 Ca(2+) channels, CNGC18 was the only one essential for pollen tube guidance. Its transmembrane domains are needed for this function. Point mutations R491Q or R578K resulted in abnormal Ca(2+) gradients and strong pollen tube guidance defects. PMID: 26929345
    3. Arabidopsis CNGC18 is a Ca(2)-permeable channel PMID: 24380879
    4. CNGCs have a widespread role in regulating cell-growth dynamics in both plant and animals PMID: 17726111
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
  • 组织特异性：
    Expressed in pollen grains. Not detected in leaves, roots or root hairs.
  • 数据库链接：

    KEGG: ath:AT5G14870

    STRING: 3702.AT5G14870.1

    UniGene: At.31874