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  4. Recombinant Human MARVEL domain-containing protein 3 (MARVELD3)

Recombinant Human MARVEL domain-containing protein 3 (MARVELD3)

  • 中文名称：
    人MARVELD3重组蛋白
  • 货号：
    CSB-CF842633HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    MARVELD3
  • Uniprot No.：
  • 别名：
    MARVELD3; MRVLDC3; MARVEL domain-containing protein 3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-401
  • 氨基酸序列
    MEDPSGAREPRARPRERDPGRRPHPDQGRTHDRPRDRPGDPRRKRSSDGNRRRDGDRDPE RDQERDGNRDRNRDRERERERERDPDRGPRRDTHRDAGPRAGEHGVWEKPRQSRTRDGAR GLTWDAAAPPGPAPWEAPEPPQPQRKGDPGRRRPESEPPSERYLPSTPRPGREEVEYYQS EAEGLLECHKCKYLCTGRACCQMLEVLLNLLILACSSVSYSSTGGYTGITSLGGIYYYQF GGAYSGFDGADGEKAQQLDVQFYQLKLPMVTVAMACSGALTALCCLFVAMGVLRVPWHCP LLLVTEGLLDMLIAGGYIPALYFYFHYLSAAYGSPVCKERQALYQSKGYSGFGCSFHGAD IGAGIFAALGIVVFALGAVLAIKGYRKVRKLKEKPAEMFEF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As a component of tight junctions, plays a role in paracellular ion conductivity.
  • 基因功能参考文献：
    1. MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival. PMID: 24567356
    2. MarvelD3 is transcriptionally downregulated in Snail-induced epithelial-mesenchymal transition during the progression for the pancreatic cancer. PMID: 21763689
    3. marvelD3, occludin, and tricellulin define the tight junction-associated MARVEL protein family PMID: 20164257
    4. MarvelD3 co-localises with occludin at tight junctions in intestinal and corneal epithelial cells. PMID: 20028514
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Cell junction, tight junction.
  • 数据库链接：

    HGNC: 30525

    OMIM: 614094

    KEGG: hsa:91862

    UniGene: Hs.513706