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  4. Recombinant Mouse Claudin-11 (Cldn11)

Recombinant Mouse Claudin-11 (Cldn11)

  • 中文名称：
    Recombinant Mouse Claudin-11(Cldn11)
  • 货号：
    CSB-CF717131MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Cldn11
  • Uniprot No.：
  • 别名：
    Cldn11; Osp; Otm; Claudin-11; Oligodendrocyte transmembrane protein; Oligodendrocyte-specific protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-207
  • 氨基酸序列
    MVATCLQVVGFVTSFVGWIGIIVTTSTNDWVVTCSYTIPTCRKMDELGSKGLWADCVMAT GLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGHEPGVAKYRRA QLAGVLLILLALCAIVATIWFPVCAHREITIVSFGYSLYAGWIGAVMCLVGGCVIVCCSG DAQSFGENRFYYSSGSSSPTHAKSAHV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能参考文献：
    1. Absence of claudin 11 in CNS myelin causes behavioral phenotypes and neurotransmitter imbalances in amygdala and auditory brainstem PMID: 29491447
    2. Results show that the primary function of claudin-11 is to provide a barrier that impedes the diffusion of material through the intramyelinic compartment PMID: 26445439
    3. The present study provides the first evidence that DPT may be a novel effector of cadmium chloride, highlighting the significant role of DPT in the regulation of claudin-11 expression PMID: 24909373
    4. Local radiation-induced testicular oxidative stress can elevate the expression of claudin-11 in the testis tissue. PMID: 23678707
    5. Peptide octamers to modify the course of relapsing experimental autoimmune encephalomyelitis in SJL mice immunized with an oliogodendrocyte-specific protein peptide (OSP 55-71). PMID: 23611642
    6. Spermatogenesis in all founder mice harboring two copies of the endogenous Cldn11 gene was normal. The promoter/enhancer of the transgene, upstream of exon 1 of the Cldn11 gene, is sufficient to rescue azoospermia in Cldn11-null mice. PMID: 22378758
    7. we identified Cldn1, Cldn2 and Cldn11 as genes that discriminate between diverse types of M2 macrophages PMID: 22268650
    8. Cldn11(-/-) Sertoli cells exhibit a unique phenotype whereby loss of tight junction integrity results in loss of the epithelial phenotype. PMID: 19741204
    9. claudin-11 has a role in forming tight junctions in stria vascularis required for hearing through generation of endocochlear potential PMID: 15456848
    10. These data demonstrate that OSP/claudin-11 and PLP have essential structural functions in maintaining normal compact myelin and there is redundancy in their functions. PMID: 15886014
    11. Autoimmune T and B cell responses and the clinical and pathological manifestations associated with OSP-induced experimental allergic encephalomyelitis and optic neuritis in SJL/J mice are characterized. PMID: 17082656
    12. This study identifies claudin-11 protein overexpression in mouse ovarian serous cystadenoma. PMID: 17217615
    13. We generated claudin 11/claudin 14 double-deficient mice, which exhibit deafness, neurological deficits, and male sterility. Kidney function and ion balance are not significantly affected. PMID: 18663477
    14. Claudin 11 tight junctions improve the resistive properties of myelin sheaths for small axons in the central nervous system. PMID: 19047465
    15. The absence of claudin 11 in mouse testis arrests sperm production during meiosis. The absence of claudin 11 in brain causes a mild tremor phenotype and slowed nerve conduction. PMID: 10612400
    16. The absence of claudin 11 tight junctions in the stria vascularis of the cochlea reduces endocochlear potential but not potassium levels in the endolymph PMID: 15306639
    17. Claudin-11 is expressed in the basal cells of stria vascularis in the cochlea. PMID: 14698084

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  • 亚细胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Claudin family
  • 数据库链接：

    KEGG: mmu:18417

    STRING: 10090.ENSMUSP00000042181

    UniGene: Mm.4425