Cdk6
CDK6，即细胞周期蛋白依赖性激酶6，别名细胞分裂蛋白6、血小板来源的丝氨酸/苏氨酸激酶等。它是一种由CDK6基因编码的蛋白激酶，属于CMGC蛋白激酶家族成员，对细胞周期G1期的进展和G1/S转换具有重要作用。CDK6与D型细胞周期蛋白结合，形成复合体，通过磷酸化视网膜母细胞瘤蛋白（Rb），激活E2F转录程序，促进细胞进入S期进行DNA复制。CDK6在生物学上的意义主要体现在其对细胞周期的调控作用。它的活性对于维持细胞的正常增殖至关重要，同时CDK6也参与了细胞分化和肿瘤细胞的增殖。在肿瘤细胞中，CDK6的异常激活与多种癌症的发生发展有关，包括白血病、淋巴瘤和实体瘤等。此外，CDK6抑制剂如Palbociclib、Ribociclib和Abemaciclib已在临床上用于治疗某些类型的乳腺癌，并正在被研究用于治疗其他癌症类型。
热销产品
CDK6 Recombinant Monoclonal Antibody (CSB-RA555745A0HU)
验证数据
Western Blot
Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate, 293 whole cell lysate
All lanes: CDK6 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 37 kDa
Observed band size: 37 kDa
Immunoprecipitating CDK6 in K562 whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-RA555745A0HU in K562 whole cell lysate.
For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-RA555745A0HU(2µg)+ K562 whole cell lysate(500µg)
Lane 3: K562 whole cell lysate (10µg)
Cdk6 Antibodies
Cdk6 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA005074GA01HU | CDK6 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA549404 | Phospho-CDK6 (Tyr13) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA267478 | Phospho-CDK6 (Tyr24) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA090625 | CDK6 (Ab-13) Antibody | Human,Mouse | ELISA,IHC,IF |
| CSB-PA564539 | CDK6 (Ab-24) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA871419 | CDK6 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA245607 | CDK6 Antibody | Human | WB, IHC, ELISA |
| CSB-PA005074LA01HU | CDK6 Antibody | Human | ELISA, IHC, IF |
| CSB-PA005074LB01HU | CDK6 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA005074LC01HU | CDK6 Antibody, FITC conjugated | Human | |
| CSB-PA005074LD01HU | CDK6 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA555745A0HU | CDK6 Recombinant Monoclonal Antibody | Human | ELISA, WB, IP |
Cdk6 Proteins
Cdk6 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005074MO CSB-EP005074MO CSB-BP005074MO CSB-MP005074MO CSB-EP005074MO-B |
Recombinant Mouse Cyclin-dependent kinase 6 (Cdk6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
